A review of analytical techniques and their application in disease diagnosis in breathomics and salivaomics research

Beale, D, Jones, O, Karpe, A, Dayalan, S, Oh, D, Kouremenos, K, Ahmed, W and Palombo, E 2016, 'A review of analytical techniques and their application in disease diagnosis in breathomics and salivaomics research', International Journal of Molecular Sciences, vol. 18, no. 1, 24, pp. 1-26.


Document type: Journal Article
Collection: Journal Articles

Title A review of analytical techniques and their application in disease diagnosis in breathomics and salivaomics research
Author(s) Beale, D
Jones, O
Karpe, A
Dayalan, S
Oh, D
Kouremenos, K
Ahmed, W
Palombo, E
Year 2016
Journal name International Journal of Molecular Sciences
Volume number 18
Issue number 1
Article Number 24
Start page 1
End page 26
Total pages 26
Publisher MDPIAG
Abstract The application of metabolomics to biological samples has been a key focus in systems biology research, which is aimed at the development of rapid diagnostic methods and the creation of personalized medicine. More recently, there has been a strong focus towards this approach applied to non-invasively acquired samples, such as saliva and exhaled breath. The analysis of these biological samples, in conjunction with other sample types and traditional diagnostic tests, has resulted in faster and more reliable characterization of a range of health disorders and diseases. As the sampling process involved in collecting exhaled breath and saliva is non-intrusive as well as comparatively low-cost and uses a series of widely accepted methods, it provides researchers with easy access to the metabolites secreted by the human body. Owing to its accuracy and rapid nature, metabolomic analysis of saliva and breath (known as salivaomics and breathomics, respectively) is a rapidly growing field and has shown potential to be effective in detecting and diagnosing the early stages of numerous diseases and infections in preclinical studies. This review discusses the various collection and analyses methods currently applied in two of the least used non-invasive sample types in metabolomics, specifically their application in salivaomics and breathomics research. Some of the salient research completed in this field to date is also assessed and discussed in order to provide a basis to advocate their use and possible future scientific directions.
Subject Medical Biochemistry: Amino Acids and Metabolites
Metabolic Medicine
Keyword(s) Bioinformatics
Breath
Gas chromatography
Liquid chromatography
Mass spectrometry
Metabolomics
Saliva
DOI - identifier 10.3390/ijms18010024
Copyright notice © 2016 by the authors
ISSN 1422-0067
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 15 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
Altmetric details:
Access Statistics: 130 Abstract Views  -  Detailed Statistics
Created: Thu, 23 Feb 2017, 10:59:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us