An update on clinical drug interactions with the herbal antidepressant St. John's wort

Zhou, S and Lai, X 2008, 'An update on clinical drug interactions with the herbal antidepressant St. John's wort', Current Drug Metabolism, vol. 9, no. 5, pp. 394-409.


Document type: Journal Article
Collection: Journal Articles

Title An update on clinical drug interactions with the herbal antidepressant St. John's wort
Author(s) Zhou, S
Lai, X
Year 2008
Journal name Current Drug Metabolism
Volume number 9
Issue number 5
Start page 394
End page 409
Total pages 16
Publisher Bentham Science Publishers Ltd.
Abstract St. John's wort (Hypericum perforatum, SJW) is one of the most commonly used herbal antidepressants for the treatment of minor to moderate depression. Limited clinical trials suggest that hypericum and standard antidepressants have similar beneficial effects, but current evidence regarding the antidepression effects of SJW extracts is inconsistent. A major safety concern about SJW is its ability to alter the pharmacokinetics and/or clinical response of a variety of clinically important drugs. This review highlights and updates the knowledge regarding drug interactions with SJW by a systematic review of all the available evidence, including worldwide published literature and spontaneous case reports. A number of clinically significant interactions of SJW have been identified with conventional drugs. These interactions often result in a decrease in the concentration or effect of the combined drug, most probably due to the induction of cytochrome P450s (CYPs) and the key drug transporter P-glycoprotein (P-gp) by the major active constituents in SJW. SJW is a potent inducer of human CYP3A4 and P-gp in vitro and in vivo. In addition, pharmacodynamic interactions of SJW with some drugs (e.g. selective serotonin re-uptake inhibitors) have been identified, which are associated with an increased risk of adverse reactions. Since potential interactions of SJW with conventional drugs is a major safety concern, it is important to minimize and avoid these interactions by taking appropriate approaches. These include systematic research to identify SJW-drug interaction; close therapeutic drug monitoring when SJW is combined with conventional drugs with a narrow therapeutic window; proper dose and regimen adjustment; patient education and communication between the patient and physician; design of new preparations of SJW without inducing ability of CYP3A4 and P-gp while retaining its bioactivity; and appropriate regulation in herbal safety and efficacy. Further clinical and mechanistic studies are warranted to explore the interaction of SJW with other important drugs and clinical significance.
Subject Traditional Chinese Medicine and Treatments
Keyword(s) St. John's Wort
pharmacokinetics
drug interaction
toxicity
Copyright notice © 2008 Bentham Science Publishers Ltd.
ISSN 1389-2002
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