Carbon dots as fluorescent probes for "off-on" detection of Cu2+ and l-cysteine in aqueous solution

Zong, J, Yang, X, Trinchi, A, Hardin, S, Cole, I, Zhu, Y, Li, C, Muster, T and Wei, G 2014, 'Carbon dots as fluorescent probes for "off-on" detection of Cu2+ and l-cysteine in aqueous solution', Biosensors and Bioelectronics, vol. 51, pp. 330-335.


Document type: Journal Article
Collection: Journal Articles

Title Carbon dots as fluorescent probes for "off-on" detection of Cu2+ and l-cysteine in aqueous solution
Author(s) Zong, J
Yang, X
Trinchi, A
Hardin, S
Cole, I
Zhu, Y
Li, C
Muster, T
Wei, G
Year 2014
Journal name Biosensors and Bioelectronics
Volume number 51
Start page 330
End page 335
Total pages 6
Publisher Elsevier
Abstract Copper ion (Cu2+) and L-cysteine (L-Cys) detection is critically important since an abnormal level of Cu2+ or L-Cys is an indicator for many diseases. In this paper, we demonstrate an "off-on" approach for highly sensitive and selective detection of Cu2+ and L-Cys using carbon dots (CDs) as fluorescent probes. CDs were prepared by using mesoporous silica (MS) spheres as nanoreactors. The binding ability of CDs towards metal ions was examined by comparing the fluorescence intensities of CDs before and after the addition of the metal ions. The addition of Cu2+ cations leads to their absorption on the surface of CDs and the significant fluorescence quench of CDs (turn-off). The resulting in CDs-Cu2+ system was found to be sensitive to L-Cys. The addition of L-Cys not only serves to shelter the CDs effectively from being quenched, but also to reverse the quenching and restore the fluorescence (turn-on) due to its ability to remove Cu2+ from the surface of CDs. This method is facile, rapid, low cost, and environment-friendly. A detection limit as low as 2.3 x 10(-8) M for Cu2+ and 3.4 x 10(-10) M for L-Cys is obtained, which is promising for biological applications.
Subject Materials Engineering not elsewhere classified
Keyword(s) Mesoporous silica
Carbon dots
Fluorescent probe
Copper ions
L-cysteine
"off-on" detection
DOI - identifier 10.1016/j.bios.2013.07.042
Copyright notice © 2013 Elsevier B.V.
ISSN 0956-5663
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