CEACAM2 positively regulates integrin alpha(IIb)beta(3)-mediated platelet functions

Alshahrani, M, Kyriacou, R, O'Malley, C, Heinrich, G, Najjar, S and Jackson, D 2016, 'CEACAM2 positively regulates integrin alpha(IIb)beta(3)-mediated platelet functions', Platelets, vol. 27, no. 8, pp. 743-750.


Document type: Journal Article
Collection: Journal Articles

Title CEACAM2 positively regulates integrin alpha(IIb)beta(3)-mediated platelet functions
Author(s) Alshahrani, M
Kyriacou, R
O'Malley, C
Heinrich, G
Najjar, S
Jackson, D
Year 2016
Journal name Platelets
Volume number 27
Issue number 8
Start page 743
End page 750
Total pages 8
Publisher Taylor and Francis
Abstract Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), is an Ig-ITIM superfamily member that regulates integrin alphaIIbbeta3 function. We hypothesised that its twin protein, CEACAM2, exerts a similar physiologic role in murine platelets. Ceacam2-deficient mice (Cc2-/-) displayed prolonged tail bleeding times and increased volume of blood lost. Cc2-/- platelets have moderate integrin alphaIIbbeta3 mediated functional defects with impaired kinetics of platelet spreading on fibrinogen and type I collagen and delayed kinetics in retraction of fibrin clots in vitro. This functional integrin alphaIIbbeta3 defect could not be attributed to altered integrin alphaIIbbeta3 expression. Cc2-/- platelets displayed normal 'inside-out' signalling properties as demonstrated by normal agonist-induced binding of soluble FITC-fibrinogen and JON/A antibody binding. This data provides direct evidence that disruption of CEACAM2 induces a moderate integrin alphaIIbbeta3-mediated platelet function defect, and that CEACAM2
Subject Haematology
Cardiovascular Medicine and Haematology not elsewhere classified
Keyword(s) ceacam2
integrin alphaIIbbeta3
platelet functional defects
DOI - identifier 10.3109/09537104.2016.1171834
Copyright notice © 2016 Taylor and Francis
ISSN 0953-7104
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