A novel and facile approach to fabricate a conductive and biomimetic fibrous platform with sub-micron and micron features

Esrafilzadeh, D, Jalili, R, Liu, X, Gilmore, K, Razal, J, Moulton, S and Wallace, G 2016, 'A novel and facile approach to fabricate a conductive and biomimetic fibrous platform with sub-micron and micron features', Journal of Materials Chemistry B, vol. 4, no. 6, pp. 1056-1063.


Document type: Journal Article
Collection: Journal Articles

Title A novel and facile approach to fabricate a conductive and biomimetic fibrous platform with sub-micron and micron features
Author(s) Esrafilzadeh, D
Jalili, R
Liu, X
Gilmore, K
Razal, J
Moulton, S
Wallace, G
Year 2016
Journal name Journal of Materials Chemistry B
Volume number 4
Issue number 6
Start page 1056
End page 1063
Total pages 8
Publisher Royal Society of Chemistry
Abstract The demands of multifunctional scaffolds have exceeded the passive biocompatible properties previously considered sufficient for tissue engineering. Herein, a novel and facile method used to fabricate a core-shell structure consisting of a conducting fiber core and an electrospun fiber shell is presented. This multifunctional structure simultaneously provides the high conductivity of conducting polymers as well as the enhanced interactions between cells and the sub-micron topographical environments provided by highly aligned cytocompatible electrospun fibers. Unlimited lengths of PEDOT:PSS-Chitosan-PLGA fibers loaded with an antibiotic drug, ciprofloxacin hydrochloride, were produced using this method. The fibers provide modulated drug release with excellent mechanical properties, electrochemical performance and cytocompatibility, which hold great promise for the application of conductive electrospun scaffolds in regenerative medicine.
Subject Regenerative Medicine (incl. Stem Cells and Tissue Engineering)
DOI - identifier 10.1039/c5tb02237a
Copyright notice © The Royal Society of Chemistry 2016
ISSN 2050-7518
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