Antidiabetic, lipid normalizing, and nephroprotective actions of the strawberry: A potent supplementary fruit

Mandave, P, Khadke, S, Karandikar, M, Pandit, V, Ranjekar, P, Kuvalekar, A and Mantri, N 2017, 'Antidiabetic, lipid normalizing, and nephroprotective actions of the strawberry: A potent supplementary fruit', International Journal of Molecular Sciences, vol. 18, no. 1, 124, pp. 1-22.


Document type: Journal Article
Collection: Journal Articles

Title Antidiabetic, lipid normalizing, and nephroprotective actions of the strawberry: A potent supplementary fruit
Author(s) Mandave, P
Khadke, S
Karandikar, M
Pandit, V
Ranjekar, P
Kuvalekar, A
Mantri, N
Year 2017
Journal name International Journal of Molecular Sciences
Volume number 18
Issue number 1
Article Number 124
Start page 1
End page 22
Total pages 22
Publisher M D P I AG
Abstract The study was designed to assess the effect of different strawberry extracts on glucose levels, lipid profiles, and oxidative stress in nicotinamide-streptozotocin (NIC-STZ) induced diabetic rats. The associated changes were evaluated through biochemical, molecular, and histological assays. Diabetes was induced by intraperitoneal injection of STZ to albino Wistar rats after treatment with nicotinamide. Aqueous, hydroalcoholic, and alcoholic strawberry extracts were administrated orally to diabetic rats. Treatment of strawberry extracts improved lipid profile, liver function, and serum creatinine and led to a significant increase in antioxidant status in diabetic rats. Real-time PCR expression analysis of genes from the liver of animals treated with strawberry extracts exhibited downregulation of several fatty acid synthesis genes, transcription factors, such as Sterol regulatory Element Binding Transcription factor (SREBP) and Nuclear Factor-Kp (NF-Kp), and inflammatory markers, like Interleukin 6 (IL6) and Tumor Necrosis Factor-a (TNF-a). Strawberry extracts also upregulated liver Peroxisome Proliferator Activated Receptor-y (PPAR-j). Histological examination confirmed the nephroprotective and p-cell regeneration/protection effects of strawberry extracts. The present study demonstrates several beneficial effects of strawberry extracts along with its probable mechanism of action.
Subject Crop and Pasture Nutrition
Keyword(s) Beta-cell regeneration/protection effects
antihyperglycemic activity
normolipidemic activity
oxidative stress
strawberry
DOI - identifier 10.3390/ijms18010124
Copyright notice © 2017 by the authors; licensee MDPI, Basel, Switzerland.
ISSN 1422-0067
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