A gut reaction: the combined influence of exercise and diet on gastrointestinal microbiota in rats

Batacan, R, Fenning, A, Dalbo, V, Scanlan, A, Duncan, M, Moore, R and Stanley, D 2017, 'A gut reaction: the combined influence of exercise and diet on gastrointestinal microbiota in rats', Journal of Applied Microbiology, vol. 122, no. 6, pp. 1627-1638.


Document type: Journal Article
Collection: Journal Articles

Title A gut reaction: the combined influence of exercise and diet on gastrointestinal microbiota in rats
Author(s) Batacan, R
Fenning, A
Dalbo, V
Scanlan, A
Duncan, M
Moore, R
Stanley, D
Year 2017
Journal name Journal of Applied Microbiology
Volume number 122
Issue number 6
Start page 1627
End page 1638
Total pages 12
Publisher Wiley-Blackwell
Abstract Aims: Intestinal microbiota modulates the development of clinical conditions, including metabolic syndrome and obesity. Many of these conditions are influenced by nutritional and exercise behaviours. This study aimed to investigate the ability of exercise to re-shape the intestinal microbiota and the influence of the diet on the process. Methods and Results: A rat model was used to examine the intestinal microbiota responses to four activity conditions, including: high-intensity interval training (HIIT), light-intensity training (LIT), sedentary and normal control, each containing two nutritional conditions: high-fat high-fructose diet (HF) and standard chow (SC) diet. No significant differences in microbiota were apparent between activity conditions in rats fed a HF diet but changes in the presence/absence of phylotypes were observed in the LIT and HIIT groups. In rats fed SC, significant differences in intestinal microbiota were evident between exercised and nonexercised rats. Both LIT and HIIT induced significant differences in intestinal microbiota in SC-fed rats compared to their respective SC-fed controls. Characterization of the exercise-induced bacterial phylotypes indicated an increase in bacteria likely capable of degrading resistant polysaccharides and an increase in short chain fatty acid producers. Conclusions: While a significant effect of exercise on microbiota composition occurred in SC-fed rats, the HF-fed rats microbiota showed little response. These data suggest that a HF diet prevented microbiota differentiation in response to exercise. Significance and Impact of the Study: The importance of diet-exercise interaction is extended to the level of intestinal bacteria and gut health.
Subject Microbial Ecology
Animal Growth and Development
Keyword(s) diet
fat
fibre
high-intensity interval training
HIIT
intestinal microbiota
light-intensity training
DOI - identifier 10.1111/jam.13442
ISSN 1364-5072
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