Anti-cancer gold(I) phosphine complexes: Cyclic trimers and tetramers containing the P-Au-P moiety

Telukutla, S, Priver, S, Mirzadeh, N and Bhargava, S 2017, 'Anti-cancer gold(I) phosphine complexes: Cyclic trimers and tetramers containing the P-Au-P moiety', Journal of Inorganic Biochemistry, vol. 175, pp. 1-8.


Document type: Journal Article
Collection: Journal Articles

Title Anti-cancer gold(I) phosphine complexes: Cyclic trimers and tetramers containing the P-Au-P moiety
Author(s) Telukutla, S
Priver, S
Mirzadeh, N
Bhargava, S
Year 2017
Journal name Journal of Inorganic Biochemistry
Volume number 175
Start page 1
End page 8
Total pages 8
Publisher Elsevier
Abstract We report the application of cationic tri- and tetra-nuclear gold(I) phosphine complexes [Au 3 (μ-dppen) 3 ]X 3 and [Au 4 (μ-dppa) 4 ]X 4 (X = OTf, PF 6 ) [OTf = trifluoromethanesulfonate, dppen = trans-1,2-bis(diphenylphosphino)ethene, dppa = bis(diphenylphosphino)acetylene] for cancer treatment. The results of cytotoxicity tests on four different cancer cells [prostate (DU145), cervical (HeLa), breast (MDAMB-231) and fibro sarcoma (HT1080)] indicate these complexes possess remarkable tumor cell growth inhibitory effects and high selectivity towards cancer cells. The anti-tumor mechanism of the tri- and tetra-nuclear gold(I) complexes has also been investigated.
Subject Bioinorganic Chemistry
Biologically Active Molecules
Medicinal and Biomolecular Chemistry not elsewhere classified
Keyword(s) Anti-cancer activity
Apoptosis
Gold phosphine complexes
Thioredoxin reductase
DOI - identifier 10.1016/j.jinorgbio.2017.06.010
Copyright notice © 2017 Elsevier Inc.
ISSN 0162-0134
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 7 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 1 times in Scopus Article | Citations
Altmetric details:
Access Statistics: 60 Abstract Views  -  Detailed Statistics
Created: Wed, 13 Sep 2017, 13:17:00 EST by Catalyst Administrator
© 2014 RMIT Research Repository • Powered by Fez SoftwareContact us