Assessing multigenerational effects of prednisolone to the freshwater snail, Physa acuta (Gastropoda: Physidae)

Bal, N, Kumar, A and Nugegoda, D 2017, 'Assessing multigenerational effects of prednisolone to the freshwater snail, Physa acuta (Gastropoda: Physidae)', Journal of Hazardous Materials, vol. 339, pp. 281-291.


Document type: Journal Article
Collection: Journal Articles

Title Assessing multigenerational effects of prednisolone to the freshwater snail, Physa acuta (Gastropoda: Physidae)
Author(s) Bal, N
Kumar, A
Nugegoda, D
Year 2017
Journal name Journal of Hazardous Materials
Volume number 339
Start page 281
End page 291
Total pages 11
Publisher Elsevier
Abstract Prednisolone (PDS), a potent synthetic glucocorticoid is widely prescribed for its exceptional anti-inflammatory properties. Several studies have detected the environmental presence of PDS in water bodies which has led to an ecological concern for its toxicity to non-target aquatic biota. The present study investigated the effects of exposure to PDS on different life-cycle stages and generations of the freshwater snail, Physa acuta. This continuous exposure over a period of multiple generations resulted in generational impairments at measured endpoints. LOEC values (p < 0.001) for PDS exposure ranged from 32 to 4 μg/L in exposed F0-F2 generations. Global DNA methylation (% 5-methyl cytosine) of adult progeny was found to be affected at higher test concentrations in comparison to the parent snails. Partially formed to completely missed growth components of shell structure and shell thinning in abnormally underdeveloped PDS exposed snails of F1 and F2 generation, was also observed in this multigenerational exposure experiment. The multigenerational study confirmed P. acuta as a promising bioindicator since critical effects of the long term glucocorticoid exposure opens up the way for further investigations on transgen erational toxicity in environmental toxicology and risk assessment and to monitor glucocorticoid pollution in aqueous ecosystem.
Subject Philosophy and Religious Studies not elsewhere classified
Keyword(s) Glucocorticoids
Multigenerational toxicity
Physa acuta
Shell structure
DOI - identifier 10.1016/j.jhazmat.2017.06.024
Copyright notice © 2017 Elsevier B.V. All rights reserved.
ISSN 0304-3894
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