Antimicrobial activity of Tulsi (Ocimum tenuiflorum) essential oil and their major constituents against three species of bacteria

Yamani, H, Pang, E, Mantri, N and Deighton, M 2016, 'Antimicrobial activity of Tulsi (Ocimum tenuiflorum) essential oil and their major constituents against three species of bacteria', Frontiers in Microbiology, vol. 7, 681, pp. 1-10.


Document type: Journal Article
Collection: Journal Articles

Title Antimicrobial activity of Tulsi (Ocimum tenuiflorum) essential oil and their major constituents against three species of bacteria
Author(s) Yamani, H
Pang, E
Mantri, N
Deighton, M
Year 2016
Journal name Frontiers in Microbiology
Volume number 7
Article Number 681
Start page 1
End page 10
Total pages 10
Publisher Frontiers Research Foundation
Abstract In recent years scientists worldwide have realized that the effective life span of any antimicrobial agent is limited, due to increasing development of resistance by microorganisms. Consequently, numerous studies have been conducted to find new alternative sources of antimicrobial agents, especially from plants. The aims of this project were to examine the antimicrobial properties of essential oils distilled from Australian-grown Ocimum tenuiflorum (Tulsi), to quantify the volatile components present in flower spikes, leaves and the essential oil, and to investigate the compounds responsible for any activity. Broth micro-dilution was used to determine the minimum inhibitory concentration (MIC) of Tulsi essential oil against selected microbial pathogens. The oils, at concentrations of 4.5 and 2.25% completely inhibited the growth of Staphylococcus aureus (including MRSA) and Escherichia colt, while the same concentrations only partly inhibited the growth of Pseudomonas aeruginosa. Of 54 compounds identified in Tulsi leaves, flower spikes, or essential oil, three are proposed to be responsible for this activity; camphor, eucalyptol and eugenol. Since S. aureus (including MRSA), P. aeruginosa and E coil are major pathogens causing skin and soft tissue infections, Tulsi essential oil could be a valuable topical antimicrobial agent for management of skin infections caused by these organisms.
Subject Complementary and Alternative Medicine not elsewhere classified
Clinical Microbiology
Keyword(s) Antimicrobial activity
Essential oil
Gas chromatography-mass spectrometry
Headspace-solid phase microextraction
Tulsi (Ocimum tenuiflorum)
DOI - identifier 10.3389/fmicb.2016.00681
ISSN 1664-302X
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Citation counts: TR Web of Science Citation Count  Cited 10 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 6 times in Scopus Article | Citations
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