Assessing the potential for trace organic contaminants commonly found in Australian rivers to induce vitellogenin in the native rainbowfish (Melanotaenia fluviatilis) and the introduced mosquitofish (Gambusia holbrooki)

Scott, P, Coleman, H, Colville, A, Lim, R, Matthews, B, McDonald, J, Miranda, A, Neale, P, Nugegoda, D, Tremblay, L and Leusch, F 2017, 'Assessing the potential for trace organic contaminants commonly found in Australian rivers to induce vitellogenin in the native rainbowfish (Melanotaenia fluviatilis) and the introduced mosquitofish (Gambusia holbrooki)', Aquatic Toxicology, vol. 185, pp. 105-120.


Document type: Journal Article
Collection: Journal Articles

Title Assessing the potential for trace organic contaminants commonly found in Australian rivers to induce vitellogenin in the native rainbowfish (Melanotaenia fluviatilis) and the introduced mosquitofish (Gambusia holbrooki)
Author(s) Scott, P
Coleman, H
Colville, A
Lim, R
Matthews, B
McDonald, J
Miranda, A
Neale, P
Nugegoda, D
Tremblay, L
Leusch, F
Year 2017
Journal name Aquatic Toxicology
Volume number 185
Start page 105
End page 120
Total pages 16
Publisher Elsevier
Abstract In Australia, trace organic contaminants (TrOCs) and endocrine active compounds (EACs) have been detected in rivers impacted by sewage effluent, urban stormwater, agricultural and industrial inputs. It is unclear whether these chemicals are at concentrations that can elicit endocrine disruption in Australian fish species. In this study, native rainbowfish (Melanotaenia fluviatilis) and introduced invasive (but prevalent) mosquitofish (Gambusia holbrooki) were exposed to the individual compounds atrazine, estrone, bisphenol A, propylparaben and pyrimethanil, and mixtures of compounds including hormones and personal care products, industrial compounds, and pesticides at environmentally relevant concentrations. Vitellogenin (Vtg) protein and liver Vtg mRNA induction were used to assess the estrogenic potential of these compounds. Vtg expression was significantly affected in both species exposed to estrone at concentrations that leave little margin for safety (p < 0.001). Propylparaben caused a small but statistically significant 3× increase in Vtg protein levels (p = 0.035) in rainbowfish but at a concentration 40× higher than that measured in the environment, therefore propylparaben poses a low risk of inducing endocrine disruption in fish. Mixtures of pesticides and a mixture of hormones, pharmaceuticals, industrial compounds and pesticides induced a small but statistically significant increase in plasma Vtg in rainbowfish, but did not affect mosquitofish Vtg protein or mRNA expression. These results suggest that estrogenic activity represents a low risk to fish in most Australian rivers monitored to-date except for some species of fish at the most polluted sites.
Subject Environmental Impact Assessment
Keyword(s) EDC
Environmental estrogen
Environmental risk assessment
In vivo
Micropollutant
PPCP
DOI - identifier 10.1016/j.aquatox.2017.02.008
Copyright notice © 2017 Elsevier B.V.
ISSN 0166-445X
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