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Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria Armistead, J, Morlais, I, Mathias, D, Jardim, J and Plebanski, M 2014, 'Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria', Infection and Immunity, vol. 82, no. 2, pp. 818-829. Document type: Journal Article Collection: Journal Articles Title Antibodies to a single, conserved epitope in anopheles APN1 inhibit universal transmission of plasmodium falciparum and plasmodium vivax malaria Author(s) Armistead, J Morlais, I Mathias, D Jardim, J Plebanski, M Year 2014 Journal name Infection and Immunity Volume number 82 Issue number 2 Start page 818 End page 829 Total pages 12 Publisher American Society for Microbiology Abstract Malaria transmission-blocking vaccines (TBVs) represent a promising approach for the elimination and eradication of this disease. AnAPN1 is a lead TBV candidate that targets a surface antigen on the midgut of the obligate vector of the Plasmodium parasite, the Anopheles mosquito. In this study, we demonstrated that antibodies targeting AnAPN1 block transmission of Plasmodium falciparum and Plasmodium vivax across distantly related anopheline species in countries to which malaria is endemic. Using a biochemical and immunological approach, we determined that the mechanism of action for this phenomenon stems from antibody recognition of a single protective epitope on AnAPN1, which we found to be immunogenic in murine and nonhuman primate models and highly conserved among anophelines. These data indicate that AnAPN1 meets the established target product profile for TBVs and suggest a potential key role for an AnAPN1-based panmalaria TBV in the effort to eradicate malaria. Subject Immunology not elsewhere classified DOI - identifier 10.1128/IAI.01222-13 Copyright notice © 2014, American Society for Microbiology. ISSN 0019-9567 Related Links Link Description https://dx.doi.org/10.1128/IAI.01222-13 Link to Published Version   Versions Version Filter Type Mon, 10 Dec 2018, 13:30:05 EST Mon, 12 Aug 2019, 14:48:40 EST Filtered Full Citation counts:   Cited 33 times in Thomson Reuters Web of Science Article | Citations Cited 0 times in Scopus Article Altmetric details: Access Statistics: 4 Abstract Views  -  Detailed Statistics Created: Thu, 06 Dec 2018, 10:39:00 EST by Catalyst Administrator