Agrochemicals increase risk of human schistosomiasis by supporting higher densities of intermediate hosts

Halstead, N, Hoover, C, Arakala, A, Civitello, D, De Leo, G, Gambhir, M, Johnson, S, Jouanard, N, Loerns, K, McMahon, T, Ndione, R, Nguyen, K, Raffel, T, Remais, J, Riveau, G, Sokolow, S and Rohr, J 2018, 'Agrochemicals increase risk of human schistosomiasis by supporting higher densities of intermediate hosts', Nature Communications, vol. 9, no. 1, pp. 1-10.


Document type: Journal Article
Collection: Journal Articles

Title Agrochemicals increase risk of human schistosomiasis by supporting higher densities of intermediate hosts
Author(s) Halstead, N
Hoover, C
Arakala, A
Civitello, D
De Leo, G
Gambhir, M
Johnson, S
Jouanard, N
Loerns, K
McMahon, T
Ndione, R
Nguyen, K
Raffel, T
Remais, J
Riveau, G
Sokolow, S
Rohr, J
Year 2018
Journal name Nature Communications
Volume number 9
Issue number 1
Start page 1
End page 10
Total pages 10
Publisher Nature
Abstract Schistosomiasis is a snail-borne parasitic disease that ranks among the most important water-based diseases of humans in developing countries. Increased prevalence and spread of human schistosomiasis to non-endemic areas has been consistently linked with water resource management related to agricultural expansion. However, the role of agrochemical pollution in human schistosome transmission remains unexplored, despite strong evidence of agrochemicals increasing snail-borne diseases of wildlife and a projected 2- to 5-fold increase in global agrochemical use by 2050. Using a field mesocosm experiment, we show that environmentally relevant concentrations of fertilizer, a herbicide, and an insecticide, individually and as mixtures, increase densities of schistosome-infected snails by increasing the algae snails eat and decreasing densities of snail predators. Epidemiological models indicate that these agrochemical effects can increase transmission of schistosomes. Identifying agricultural practices or agrochemicals that minimize disease risk will be critical to meeting growing food demands while improving human wellbeing.
Subject Microbiology not elsewhere classified
Keyword(s) Prawn Macrobrachium-Rosenbergii
Crayfish Procambarus-Clarkii
Laboratory Populations
Trematocranus-Placodon
Bulinus-Nyassanus
Snail Populations
Lake Malawi
Biomphalaria
Infection
Predation
DOI - identifier 10.1038/s41467-018-03189-w
Copyright notice © 2018 The Author(s) Open Access This article is licensed under a Creative Commons Attribution 4.0 International License
ISSN 2041-1723
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