Carbon Nanotubes and Graphene as Nanoreinforcements in Metallic Biomaterials: a Review

Munir, K, Wen, C and Li, Y 2019, 'Carbon Nanotubes and Graphene as Nanoreinforcements in Metallic Biomaterials: a Review', Advanced Biosystems, vol. 3, pp. 1-24.

Document type: Journal Article
Collection: Journal Articles

Title Carbon Nanotubes and Graphene as Nanoreinforcements in Metallic Biomaterials: a Review
Author(s) Munir, K
Wen, C
Li, Y
Year 2019
Journal name Advanced Biosystems
Volume number 3
Start page 1
End page 24
Total pages 24
Publisher Wiley
Abstract Current challenges in existing metallic biomaterials encourage undertaking research in the development of novel materials for biomedical applications. This paper critically reviews the potential of carbon nanotubes (CNT) and graphene as nanoreinforcements in metallic biomaterials for bone tissue engineering. Unique and remarkable mechanical, electrical, and biological properties of these carbon nanomaterials allow their use as secondary-phase reinforcements in monolithic biomaterials. The nanoscale dimensions and extraordinarily large surface areas of CNT and graphene make them suitable materials for purposeful reaction with living organisms. However, the cyto-compatibility of CNT and graphene is still a controversial issue that impedes advances in utilizing these promising materials in clinical orthopedic applica-tions. The interaction of CNT and graphene with biological systems including proteins, nucleic acids, and human cells is critically reviewed to assess their cytocompatibity in vitro and in vivo. It is revealed that composites rein-forced with CNT and graphene show enhanced adhesion of osteoblast cells, which subsequently promotes bone tissue formation in vivo. This potential is expected to pave the way for developing ground-breaking technologies in regenerative medicine and bone tissue engineering. In addition, current progress and future research directions are highlighted for the development of CNT and graphene reinforced implants for bone tissue engineering.
Subject Biomaterials
Composite and Hybrid Materials
Keyword(s) bone tissue engineering
carbon nanotubes
metallic biomaterials
DOI - identifier 10.1002/adbi.201800212
Copyright notice © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
ISSN 2366-7478
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