Bombesin conjugated solid lipid nanoparticles for improved delivery of epigallocatechin gallate for breast cancer treatment

Radhakrishnan, R, Kulhari, D, Kulhari, H, Gudem, S, Ravuri, H, Bhargava, S and Ramakrishna, S 2019, 'Bombesin conjugated solid lipid nanoparticles for improved delivery of epigallocatechin gallate for breast cancer treatment', Chemistry and Physics of Lipids, vol. 224, pp. 1-9.


Document type: Journal Article
Collection: Journal Articles

Title Bombesin conjugated solid lipid nanoparticles for improved delivery of epigallocatechin gallate for breast cancer treatment
Author(s) Radhakrishnan, R
Kulhari, D
Kulhari, H
Gudem, S
Ravuri, H
Bhargava, S
Ramakrishna, S
Year 2019
Journal name Chemistry and Physics of Lipids
Volume number 224
Start page 1
End page 9
Total pages 9
Publisher Elsevier Ireland Ltd
Abstract Epigallocatechin-gallate (EGCG) is a potent anti-cancer therapeutic which effectively controls the growth of cancerous cells through a variety of different pathways. However, its molecular structure is susceptible to modifications due to cellular enzymes affecting its stability, bioavailability and hence, overall efficiency. In this study, we have initially encapsulated EGCG in the matrix of solid lipid nanoparticles to provide a stable drug carrier. To confer additional specificity towards gastrin releasing peptide receptors (GRPR) overexpressed in breast cancer, EGCG loaded nanoparticles were conjugated with a GRPR-specific peptide. In-vitro cytotoxicity studies showed that the peptide-conjugated formulations possessed greater cytotoxicity to cancer cell lines compared to the non-conjugated formulations. Further, in-vivo studies performed on C57/BL6 mice showed greater survivability and reduction in tumour volume in mice treated with peptide-conjugated formulation as compared to the mice treated with non-conjugated formulation or with plain EGCG. These results warrant the potential of the system designed in this study as a novel and effective drug delivery system in breast cancer therapy.
Subject Nanotechnology not elsewhere classified
Keyword(s) Bombesin
Breast cancer
Drug targeting
Epigallocatechin gallate (EGCG)
Solid lipid nanoparticles
Survival rate
DOI - identifier 10.1016/j.chemphyslip.2019.04.005
Copyright notice © 2019 Published by Elsevier B.V.
ISSN 0009-3084
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