A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy

Al-Hatamleh, M, Ahmad, S, Boer, J, Lim, J, Chen, X, Plebanski, M and Mohamud, R 2019, 'A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy', Journal of Oncology, vol. 2019, pp. 1-13.


Document type: Journal Article
Collection: Journal Articles

Title A Perspective Review on the Role of Nanomedicine in the Modulation of TNF-TNFR2 Axis in Breast Cancer Immunotherapy
Author(s) Al-Hatamleh, M
Ahmad, S
Boer, J
Lim, J
Chen, X
Plebanski, M
Mohamud, R
Year 2019
Journal name Journal of Oncology
Volume number 2019
Start page 1
End page 13
Total pages 13
Publisher Hindawi Publishing Corporation
Abstract In the past decade, nanomedicine research has provided us with highly useful agents (nanoparticles) delivering therapeutic drugs to target cancer cells. The present review highlights nanomedicine applications for breast cancer immunotherapy. Recent studies have suggested that tumour necrosis factor (TNF) and its receptor 2 (TNFR2) expressed on breast cancer cells have important functional consequences. This cytokine/receptor interaction is also critical for promoting highly immune-suppressive phenotypes by regulatory T cells (Tregs). This review generally provides a background for nanoparticles as potential drug delivery agents for immunomodulators and further discusses in depth the potential of TNF antagonists delivery to modulate TNF-TNFR2 interactions and inhibit breast cancer progression.
Subject Clinical Sciences not elsewhere classified
DOI - identifier 10.1155/2019/6313242
Copyright notice © 2019 Mohammad A. I. Al-Hatamleh et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
ISSN 1687-8450
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