Association of cyclooxygenase-1dependent and independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization

Frelinger, A, Li, Y, Linden, M, Barnard, M, Fox, M, Christe, D, Furman, M and Michelson, A 2009, 'Association of cyclooxygenase-1dependent and independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization', Circulation: Journal of the American Heart Association, vol. 125, no. 26, pp. 2586-2596.


Document type: Journal Article
Collection: Journal Articles

Title Association of cyclooxygenase-1dependent and independent platelet function assays with adverse clinical outcomes in aspirin-treated patients presenting for cardiac catheterization
Author(s) Frelinger, A
Li, Y
Linden, M
Barnard, M
Fox, M
Christe, D
Furman, M
Michelson, A
Year 2009
Journal name Circulation: Journal of the American Heart Association
Volume number 125
Issue number 26
Start page 2586
End page 2596
Total pages 11
Publisher American Heart Association
Abstract Poor clinical outcome in aspirin-treated patients has been termed aspirin resistance and may result from inadequate inhibition of platelet cyclooxygenase-1 (COX-1) by aspirin. The objectives of this study were to determine prospectively whether COX-1-dependent and other platelet function assays correlate with clinical outcomes in aspirin-treated patients.
Subject Cardiology (incl. Cardiovascular Diseases)
Keyword(s) aspirin
myocardial infarction
platelets
revascularization
thromboxane
DOI - identifier 10.1161/CIRCULATIONAHA.109.900589
Copyright notice American Heart Association 2009
ISSN 1524-4539
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