Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus

McPhee, S, Hodges, L, Wright, P, Wynne, P, Kalafatis, N, Harney, D and Macrides, T 2007, 'Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus', Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology, vol. 146, pp. 346-356.


Document type: Journal Article
Collection: Journal Articles

Title Anti-cyclooxygenase effects of lipid extracts from the New Zealand green-lipped mussel, Perna canaliculus
Author(s) McPhee, S
Hodges, L
Wright, P
Wynne, P
Kalafatis, N
Harney, D
Macrides, T
Year 2007
Journal name Comparative Biochemistry and Physiology. Part B: Biochemistry and Molecular Biology
Volume number 146
Start page 346
End page 356
Total pages 11
Publisher Elsevier Science
Abstract Total lipid extracts of P. canaliculus (a bivalve marine mollusc native to New Zealand, commonly called the green-ripped mussel) and Mytilus edulis (commonly called the common blue mussel) moderately inhibited ovine COX-1 and COX-2 pure enzymes in vitro. The inhibition was increased after the mussel extracts were saponified by KOH hydrolysis. Protease- and protease-lipase-hydrolysed lipid extracts of P. canaliculus exhibited similarly strong COX inhibition as the KOH-hydrolysed extract. Lyprinol (R) (a commercial extract from P. canaliculus) also exhibited strong inhibition of both COX isoforms, an effect that was increased 10-fold upon subsequent hydrolysis. In contrast, fish oil was not as anti-COX active as Lyprinol. The Lyprinol free fatty acid fraction, and to a lesser extent the Lyprinol triglyceride fraction, were the only lipid classes of Lyprinol to exhibit strong inhibition of the COX isoforms. The purified PUFA extracts were all bioactive, potently inhibiting COX-1 and COX-2. Incubation of Lyprinol in the absence of exogenous arachidonic acid (AA) showed the appearance of alternate prostaglandin metabolites, confirming Lyprinol PUFA as a competitive substrate inhibitor of AA metabolism.
Keyword(s) Polyunsaturated Fatty-Acids
Prostaglandin-H Synthase
Mytilus-Edulis
Sterol Composition
Inhibition
Disease
Phytoplankton
Biosynthesis
Consumption
Activation
DOI - identifier 10.1016/j.cbpb.2006.11.001
Copyright notice © 2006 Elsevier Inc. All rights reserved.
ISSN 1096-4959
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